Ceftazidime Ep Impurity E
Ceftazidime t-Butyl Ester
CAS: 102772-66-7
Molecular Formula: C26H30N6O7S2
Ceftazidime Ep Impurity E - Names and Identifiers
Ceftazidime Ep Impurity E - Physico-chemical Properties
| Molecular Formula | C26H30N6O7S2 |
| Molar Mass | 602.6824 |
| Melting Point | >195°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Off-Whte to Brown |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Ceftazidime Ep Impurity E - Reference Information
| introduction | the impurity most likely to be generated in the preparation process of ceftazidime is a trace amount of the impurity in the process of synthesizing ceftazidime tert-butyl ester or ceftazidime active ester raw material. |
| preparation | a preparation method of ceftazidime tert-butyl ester: add 520ml of chloroform and 30ml of tert-butanol into a clean and dry four-port reaction bottle, and cool down to 0-5 ℃. Add 7-APCA70g and tadine active ester 105g, control the temperature and drop triethylamine, and adjust the PH to 7.0-9.0. The temperature is controlled at 0-10 ℃ for 20-24 hours. After the reaction, add 150ml of pure water, stir for 1-2 hours, and separate chloroform. Dropping isopropanol into the liquid medicine to precipitate ceftazidime tert-butyl ester, stirring at 0-10 ℃ for 2 hours. Filter by suction, wash with isopropanol, and dry to obtain dry ceftazidime tert-butyl ester. Weight yield: 145%, purity 98.9%. |
Last Update：2024-04-09 15:16:35
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Product Name: Ceftazidime Impurity 5 (Ceftazidime EP Impurity E) Visit Supplier Webpage Request for quotationCAS: 102772-66-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Ceftazidime t-Butyl Ester Visit Supplier Webpage Request for quotation
CAS: 102772-66-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 102772-66-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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